EDF Health

A new power couple: The combined impact of the microbiome and chemical exposures on disease susceptibility (Part 2 of 2)

By Allison Tracy / Published: December 19, 2011

Allison Tracy is a Chemicals Policy Fellow. EDF Health Scientist Dr. Jennifer McPartland and Senior Scientist Dr. Richard Denison contributed to this post.

In Part 1 of this two-part post, I reviewed scientific evidence that the gut microbiome interacts with ingested chemicals to influence susceptibility to obesity and diabetes.  This hypothesis is the focus of a recent review article by Suzanne Snedeker and Anthony Hay.  Having reviewed evidence of the link between the microbiome and obesity and diabetes as well as the link between chemical exposures and obesity and diabetes, we now proceed to address this question:  Can the gut microbiome act in concert with ingested synthetic chemicals to predispose people to obesity and diabetes?

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A new power couple: The combined impact of the microbiome and chemical exposures on disease susceptibility (Part 1 of 2)

By Allison Tracy / Published: December 15, 2011

Allison Tracy is a Chemicals Policy Fellow.  EDF Health Scientist Dr. Jennifer McPartland and Senior Scientist Dr. Richard Denison contributed to this post.

When you’re standing at the kitchen counter this holiday season wrestling with the nebulous world of weight gain, think about synthetic chemicals.  A good number of them are in you.  And studies show that some of them are pretty busy in there, interacting with various biological systems – including your metabolism.

But they’re not the only show in town.  Microbes are busy in your gut doing important things like digesting food and degrading harmful compounds.  But could they also influence the size of your love handles?  New science suggests that these microbes—in concert with certain chemicals—may have just this effect.

It is becoming increasingly clear that it’s not just your genes and your self control that determine your risk for obesity and related complications like diabetes.  Environmental factors are a big part of the equation, and those factors just might extend to synthetic chemicals to which you’re exposed, such as the flame retardants in your furniture and the plasticizers in food can linings.  Read More »

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Twin dangers from TCE: Widespread exposure, and now a strong link to Parkinson disease

By Jennifer McPartland / Published: November 22, 2011

Jennifer McPartland, Ph.D., is a Health Scientist.

A study published online in the Annals of Neurology last week, “Solvent Exposures and Parkinson Disease Risk in Twins,” adds to scientific evidence linking exposure to the solvent trichloroethylene, or TCE, and other common solvents with onset of Parkinson disease.  Parkinson disease is a debilitating condition well known for symptoms of trembling but can also include slowed motion, impaired posture and balance, and loss of automatic movements (e.g. blinking, arm swaying when walking).  Most unfortunately, it has no cure. 

According to the authors, this new twin study is the first confirmation in a population-based study of a significant association between exposure to TCE and incidence of Parkinson disease.    Read More »

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Gasping for breath: Asthma-inducing diisocyanates enter our homes and schools

By Jennifer McPartland / Published: July 21, 2011

Johanna Katz is a Cornell Iscoll intern at EDF.  Jennifer McPartland, Ph.D., is a Health Scientist.

Toxic chemicals called diisocyanates are long-established as occupational hazards known to cause severe respiratory problems to workers who use or are otherwise exposed to them (see here).  In fact, diisocyanates are the number one cause of workplace-induced asthma (see here and here).  Recently, potential exposure of the general public to diisocyanates has grown, as these chemicals are increasingly used in consumer products.  This is certainly a troubling trend considering that the primary health effect of these chemicals, asthma, is a massive and growing public health problem, especially among children.  And some of the newest uses of diisocyanates are in products to which children are quite likely to be exposed.

Asthma is at an all-time high, affecting more than 24 million Americans, and creating astronomical health and productivity costs upwards of $20 BILLION each year.  And while diisocyanates are but one of many contributors to the increasing rate of asthma in the general population, we surely don’t need to be bringing more products containing such chemicals into our homes, schools, and workplaces. That will only make matters worse.

So what exactly are diisocyanate chemicals, where are they found, and what’s the federal government trying to do about them?  Read on to find out.  Read More »

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What are you, really? How our microbiome mediates chemical exposures

By Allison Tracy / Published: July 5, 2011

Allison Tracy is a Chemicals Policy Fellow. Richard Denison, Ph.D., is a Senior Scientist.

For millennia people have contemplated the question “who am I?”  But how about the even more fundamental question, “what am I”?  The human body is made up of about 10 trillion cells that form our tissues and organs.  But did you know that the human gut is the home to microbes that comprise 10 times more – that is, 100 trillion – cells?  And that, while the human genome contains about 23,000 genes, there are some 3 million genes in the microbes living in the human gut?  Obviously, this complicates things.  It arguably means we could be considered to be more microbe than human!

These numbers should tip us off to the importance of what is known as our “microbiome.”  New science is shedding light on the central function of the microbiome as a mediator between external agents to which we’re exposed and the impacts of those exposures.  Recent studies show, for example, that as chemicals pass through the gastrointestinal tract, they undergo major changes in bioavailability (i.e., how easily they are taken up into our bodies) and in their toxicity.  Recognition of the role of the microbiome is shifting the playing field for toxicology in fundamental ways.   Read More »

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Chemical safety evaluation: Limitations of emerging test methods

By Jennifer McPartland / Published: June 14, 2011

Jennifer McPartland, Ph.D., is a Health Scientist. Richard Denison, Ph.D., is a Senior Scientist.

Parts in this series:      Part 1     Part 2     Part 3     Part 4

This is the fourth in a series of blog posts on new approaches that federal agencies are exploring to improve how chemicals are evaluated for safety.  In this post, we’ll discuss a number of current limitations and challenges that must be overcome if the new approaches are to fulfill their promise of transforming the current chemical safety testing paradigm.  Read More »

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