EDF Health

Shanghai diary

John Balbus, M.D., M.P.H., is Chief Health Scientist.

Some 216 delegates representing 26 countries converged on the largest city in China last week for the 7th meeting of the International Standards Organization (ISO) Technical Committee (TC 229) on Nanotechnologies.

In China, the turtle symbolizes cosmic order, strength, endurance and wisdom.  In the US, the turtle has come to symbolize slow progress and not keeping up with the times.  Which representation better captures what’s going on in ISO’s TC 229?   Maybe a little of both. Read More »

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The Nano Risk Framework Gets Ready for Shanghai

John Balbus, M.D., M.P.H., is Chief Health Scientist.

At its most recent meeting a few weeks ago, the US Technical Advisory Group (TAG) to the International Standards Organization (ISO) Technical Committee on Nanotechnologies approved a motion to have ISO develop a Technical Report based on the EDF-Dupont Nano Risk Framework (NRF). Or to put it another way in acronym-laden Washington-speak, the US TAG to the ANSI-accredited ISO TC229 approved a TR based on the EDF-DD NRF. Read More »

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The Next Mile Marker on the Road to High Throughput In Vitro Screening?

John Balbus, M.D., M.P.H., is Chief Health Scientist.

A new paper by Shaw et al., published in May in the Proceedings of the National Academy of Sciences, “suggests a generalizable and scalable method for the systematic characterization and comparison of novel nanomaterials” using high throughput in vitro tests.  Does this mean that the National Academy of Sciences’ vision for toxicity testing in the 21st century – proposed for conventional chemicals – is already here for nanomaterials?  Not quite.  Read More »

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Are Multi-Walled Carbon Nanotubes More Like Asbestos Than We Thought? Part II

John Balbus, M.D., M.P.H., is Chief Health Scientist.

A new study published today in Nature Nanotechnology finds that multi-walled carbon nanotubes (MWCNTs) cause inflammatory changes in mice that closely resemble those caused by asbestos.  This is the second study in a few months to make this finding.  (I posted on the first, Takagi et al., a few weeks ago.)  So is the case closed on multi-walled carbon nanotubes?  Or is too early to draw conclusions? Read More »

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In Vitro Risk Assessment for a Nano Fuel Additive: Tanks or No Tanks?

John Balbus, M.D., M.P.H., is Chief Health Scientist.

The history of health and environmental impacts of fuel additives is not a pretty one.  From tetra-ethyl lead to methyl tert-butyl ether (MTBE), we’ve learned the hard way that what goes in the tank ends up in our bodies and the environment sooner or later.  Getting a thorough understanding of the potential risks of a new fuel additive at an early stage is essential to avoid a lot of harm, suffering, and economic costs down the line.

A new study by Park et al. has assessed the potential respiratory risks of a fuel additive called Envirox (nanoparticulate cerium oxide), giving it a clean bill of health based only on in vitro tests.  Is this the vision of the future of risk assessment?  Should we feel safe? Read More »

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Are Multi-Walled Carbon Nanotubes More Like Asbestos Than We Thought?

John Balbus, M.D., M.P.H., is Chief Health Scientist.

We and many others have made analogies between nanoparticles and asbestos.  The purpose of the analogy has generally been to emphasize the long latency that can occur between exposure to toxic materials and the development and subsequent recognition of disease arising from that exposure.  And, of course, the enormous legal and financial burden of failing to adequately consider risks before allowing widespread exposure.  But a new study suggests that the analogy may be even stronger than we thought:  It may extend to the capacity to cause mesothelioma, the rare form of cancer associated with exposure to asbestos. Read More »

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