{"id":8122,"date":"2018-08-17T14:18:06","date_gmt":"2018-08-17T19:18:06","guid":{"rendered":"http:\/\/blogs.edf.org\/health\/?p=8122"},"modified":"2018-08-17T14:18:06","modified_gmt":"2018-08-17T19:18:06","slug":"edf-comments-epa-tsca-systematic-review-document","status":"publish","type":"post","link":"https:\/\/blogs.edf.org\/health\/2018\/08\/17\/edf-comments-epa-tsca-systematic-review-document\/","title":{"rendered":"EDF submits extensive comments critical of EPA OPPT\u2019s TSCA systematic review document"},"content":{"rendered":"<p><em>Ryan O\u2019Connell<\/em> is a High Meadows Fellow; <em><a href=\"https:\/\/www.edf.org\/people\/jennifer-mcpartland\">Jennifer McPartland, Ph.D<\/a>., <\/em>is a Senior Scientist.<\/p>\n<p>Last night, Environmental Defense Fund (EDF) submitted critical <a href=\"https:\/\/blogs.edf.org\/health\/wp-content\/blogs.dir\/11\/files\/2018\/08\/EDF-comments-on-TSCA-systematic-review-document.pdf\">comments<\/a> on EPA\u2019s Office of Pollution Prevention and Toxics\u2019 (OPPT) \u201csystematic review\u201d <a href=\"https:\/\/www.epa.gov\/assessing-and-managing-chemicals-under-tsca\/application-systematic-review-tsca-risk-evaluations\">document<\/a> that OPPT is using to evaluate chemicals\u2019 risks under the Toxic Substances Control Act (TSCA).<\/p>\n<p>Systematic review, a hallmark of the clinical sciences, employs structured approaches to identifying, evaluating, and integrating evidence in a manner that promotes scientific rigor, consistency, transparency, objectivity, and reduction of bias.<\/p>\n<p>Unfortunately, OPPT\u2019s systematic review document deviates dramatically from the best practices in systematic review\u2014practices developed over decades based on empirical evidence and experience in application. OPPT\u2019s approach also significantly diverges from recent recommendations of the National Academy of Sciences (see <a href=\"https:\/\/www.nap.edu\/catalog\/18764\/review-of-epas-integrated-risk-information-system-iris-process\">here<\/a> and <a href=\"https:\/\/www.nap.edu\/read\/25086\/chapter\/1\">here<\/a>).<\/p>\n<p><!--more--><\/p>\n<p>The method that OPPT uses to judge individual study quality \u2013 a numerical scoring strategy \u2013 is arbitrary and vague. It is also rejected by all leading systematic review frameworks. OPPT\u2019s scoring strategy is likely to lead EPA to exclude studies in a manner inconsistent with TSCA\u2019s requirements to use the best available science and weight of the scientific evidence.<\/p>\n<p>Through this document, OPPT has introduced yet another way to dismiss important research that extends even beyond its <a href=\"https:\/\/www.edf.org\/media\/trump-and-wheelers-proposal-censor-science-imperils-life-saving-public-health-protections-all\">proposed Censored Science rule<\/a>.<\/p>\n<p>Among EDF\u2019s concerns detailed in our comments are the following:<\/p>\n<ul>\n<li>OPPT\u2019s document is not consistent with TSCA requirements:\n<ul>\n<li>OPPT\u2019s scoring approach will result in a failure of EPA to use the best available science.<\/li>\n<li>EPA cannot exclude any reasonably available information from consideration in chemical risk evaluations.<\/li>\n<\/ul>\n<\/li>\n<li>OPPT\u2019s document does not constitute systematic review as established by leading experts and scientific institutions:\n<ul>\n<li>EPA has failed to develop individual protocols for the first 10 chemicals undergoing risk evaluation.<\/li>\n<li>EPA has failed to describe its approach to data integration for the first 10 chemicals.<\/li>\n<\/ul>\n<\/li>\n<li>OPPT should not use a scoring methodology to evaluate individual studies.<\/li>\n<li>OPPT\u2019s approach to weighting study criteria is inconsistent with best practices in systematic review, and is unscientific and flatly arbitrary.<\/li>\n<li>OPPT\u2019s study evaluation criteria must be substantially revised:\n<ul>\n<li>OPPT should not conflate issues of reporting with study quality.<\/li>\n<li>OPPT should not discount or exclude studies for which underlying data are not publicly available.<\/li>\n<\/ul>\n<\/li>\n<li>OPPT must consider financial conflict of interest in the evaluation of individual studies and in the evaluation of the body of evidence.<\/li>\n<\/ul>\n<p>Ultimately, OPPT has developed a severely flawed \u201csystematic review\u201d framework. EDF urges OPPT to substantially revise its document, and subject a revised version to peer review by systematic review experts.<\/p>\n<p>See our <a href=\"https:\/\/blogs.edf.org\/health\/wp-content\/blogs.dir\/11\/files\/2018\/08\/EDF-comments-on-TSCA-systematic-review-document.pdf\">comments<\/a> for more details.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ryan O\u2019Connell is a High Meadows Fellow; Jennifer McPartland, Ph.D., is a Senior Scientist. Last night, Environmental Defense Fund (EDF) submitted critical comments on EPA\u2019s Office of Pollution Prevention and Toxics\u2019 (OPPT) \u201csystematic review\u201d document that OPPT is using to evaluate chemicals\u2019 risks under the Toxic Substances Control Act (TSCA). Systematic review, a hallmark of &#8230;<\/p>\n","protected":false},"author":118840,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[44,39263,56096,114108],"tags":[68,56107,91722,39997],"coauthors":[],"class_list":["post-8122","post","type-post","status-publish","format-standard","hentry","category-policy","category-public-health","category-omboira","category-tsca","tag-epa","tag-lautenberg-act","tag-risk-evaluation","tag-systematic-review"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"description\" content=\"Ryan O\u2019Connell is a High Meadows Fellow; Jennifer McPartland, Ph.D., is a Senior Scientist. 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Last night, Environmental Defense Fund (EDF) submitted critical comments on EPA\u2019s Office of Pollution Prevention and Toxics\u2019 (OPPT) \u201csystematic review\u201d document that OPPT is using to evaluate chemicals\u2019 risks under the Toxic Substances Control Act (TSCA). Systematic review, a hallmark of","og:url":"https:\/\/blogs.edf.org\/health\/2018\/08\/17\/edf-comments-epa-tsca-systematic-review-document\/","article:section":"EPA","article:published_time":"2018-08-17T19:18:06+00:00","article:modified_time":"2018-08-17T19:18:06+00:00","article:publisher":"https:\/\/www.facebook.com\/edfhealth","twitter:card":"summary_large_image","twitter:site":"@EDFHealth","twitter:title":"EDF submits extensive comments critical of EPA OPPT\u2019s TSCA systematic review document - EDF Health","twitter:description":"Ryan O\u2019Connell is a High Meadows Fellow; Jennifer McPartland, Ph.D., is a Senior Scientist. Last night, Environmental Defense Fund (EDF) submitted critical comments on EPA\u2019s Office of Pollution Prevention and Toxics\u2019 (OPPT) \u201csystematic review\u201d document that OPPT is using to evaluate chemicals\u2019 risks under the Toxic Substances Control Act (TSCA). Systematic review, a hallmark of","twitter:creator":"@EDFHealth"},"aioseo_meta_data":{"post_id":"8122","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"content","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":"EPA","og_article_tags":null,"twitter_use_og":true,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[],"defaultGraph":"","defaultPostTypeGraph":""},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2022-09-30 15:01:58","updated":"2025-06-06 01:52:06","seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/blogs.edf.org\/health\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/blogs.edf.org\/health\/category\/policy\/\" title=\"Health policy\">Health policy<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/blogs.edf.org\/health\/category\/policy\/omboira\/\" title=\"Regulation\">Regulation<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tEDF submits extensive comments critical of EPA OPPT\u2019s TSCA systematic review document\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/blogs.edf.org\/health"},{"label":"Health policy","link":"https:\/\/blogs.edf.org\/health\/category\/policy\/"},{"label":"Regulation","link":"https:\/\/blogs.edf.org\/health\/category\/policy\/omboira\/"},{"label":"EDF submits extensive comments critical of EPA OPPT\u2019s TSCA systematic review document","link":"https:\/\/blogs.edf.org\/health\/2018\/08\/17\/edf-comments-epa-tsca-systematic-review-document\/"}],"_links":{"self":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/8122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/users\/118840"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/comments?post=8122"}],"version-history":[{"count":0,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/8122\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/media?parent=8122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/categories?post=8122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/tags?post=8122"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/coauthors?post=8122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}