{"id":4036,"date":"2014-10-24T11:50:13","date_gmt":"2014-10-24T16:50:13","guid":{"rendered":"http:\/\/blogs.edf.org\/health\/?p=4036"},"modified":"2016-03-23T14:17:53","modified_gmt":"2016-03-23T19:17:53","slug":"building-scientific-bridges-to-support-epas-new-chemical-testing-programs","status":"publish","type":"post","link":"https:\/\/blogs.edf.org\/health\/2014\/10\/24\/building-scientific-bridges-to-support-epas-new-chemical-testing-programs\/","title":{"rendered":"Building scientific bridges to support EPA\u2019s new chemical testing programs"},"content":{"rendered":"

Jennifer McPartland, Ph.D.<\/em><\/a><\/em>,\u00a0is a Health Scientist.<\/p>\n

Readers of this blog are acutely aware of the dearth of data<\/a> available for tens of thousands of chemicals in U.S. commerce today.\u00a0 This state of ignorance reflects legal and resource constraints as well as the \u201cchallenge\u201d of continuously integrating advancements in our scientific understanding of human health and disease into the way we assess chemical toxicity.<\/p>\n

Fortunately, federal efforts to develop new chemical testing approaches<\/a>, such as the high-throughput screening programs ToxCast and Tox21, offer a great opportunity to narrow the data gap while also helping to shine light on how environmental chemicals can impact our health.\u00a0 But realizing the full potential of these new approaches will take a village.<\/p>\n

Today in Environmental Health Perspectives<\/i> we have published a commentary<\/a> \u00a0that calls for greater and more diverse engagement of the basic research community in developing and using the new federal chemical testing data. We also provide recommendations that we believe would help facilitate and improve such engagement.\u00a0 Read on to learn more. \u00a0<\/p>\n

The seminal National Research Council (NRC) report Toxicity Testing in the 21st<\/sup> Century<\/i><\/a> <\/i>(2007) emphasized the important role of the broader scientific community in achieving a paradigm shift in the way chemicals are evaluated for potential toxicity.\u00a0 That report stated that, \u201cThe broad participation of the scientific community in the elaboration of the committee\u2019s vision for toxicity testing is essential for its success.\u201d (p. 180)<\/p>\n

While the desire for such engagement may seem obvious, achieving it is proving to be anything but simple.\u00a0 EPA publicizes and hosts public meetings and monthly webinars on its chemical testing efforts, yet participation of basic environmental health researchers in these forums is low.<\/p>\n

The challenge of attracting basic researchers even into science-heavy government initiatives is certainly not unique to current federal efforts to build state-of-the -art chemical testing programs.\u00a0 As a timely case in point, the EPA Integrated Risk Information System (IRIS) program announced last week<\/a> that it will contract with the NRC to bolster the breadth of scientific input received during its bimonthly meetings, which have suffered from highly imbalanced<\/a> stakeholder participation. The announcement notes: \u201cThe involvement of NRC experts will significantly contribute to broadening the range of perspectives represented at our public meetings.\u00a0 Science and scientific integrity are the backbone of every decision, policy, and action at EPA.\u00a0 The supplementation of our ongoing public meetings with independent experts identified by the NRC will help assure that overall a full and impartial representation of the science will serve as the foundation for the IRIS Program\u2019s assessments to protect human health.\u201d\u00a0 We couldn\u2019t agree more.<\/p>\n

As a practical matter, a good part of the difficulty in attracting researchers into government initiatives is that they face competing priorities in a world of ever-dwindling research dollars.\u00a0 Compounding this resource reality is the fact that, unlike other stakeholders, research scientists don\u2019t necessarily have a direct vested interest in the outcomes of scientific government activities, which can feel quite removed from their professional lives.<\/p>\n

This is not to suggest researchers don\u2019t care.\u00a0 I believe they do.\u00a0 I came from that world. Yet the real, and in many cases severe, pressures to secure funding, to develop and maintain active research programs, and to publish mean there is little time or motivation for many researchers to become involved in government testing initiatives. We believe direct incentives are presently lacking for that community to see the value of and utilize the tools and approaches of these initiatives in their own hypothesis-based research programs.<\/p>\n

But there\u2019s good news.\u00a0 For those basic researchers studying environmental contributors to disease, there in fact is a real, tangible connection to the new federal chemical testing initiatives. EPA\u2019s ToxCast program and the interagency Tox21 program have generated millions of data points<\/a> ripe\u2014with guidance\u2014for the research picking!\u00a0 Thousands of chemicals have been tested for activity across hundreds of biological targets.\u00a0 EPA has even developed a dashboard to help external parties navigate the massive data sets.\u00a0 Of course, the data have limitations<\/a>, but we think there is opportunity for the data in synthesizing or refining hypothesizes or supplementing other types of data in studies.<\/p>\n

The challenge and the opportunity that present themselves now are to: \u00a0a) familiarize the research community with the databases and querying tools now publically available in online data files and interactive dashboards; and b) demonstrate more specifically how these emerging data may be useful in investigators\u2019 own scientific inquiries.<\/p>\n

If we can make progress here, the results stand to benefit everyone. Among other benefits, EPA will gain expert input into and review of the emerging data and investigators can pursue new avenues of research that further understanding of environmental contributors to disease.<\/p>\n

EDF is committed to helping to build bridges between the diverse scientific research community and federal chemical testing programs by expanding opportunities for engagement, inquiry, and collaboration.\u00a0 Our commentary<\/a> expands on the topics raised here and describes in more depth our recommendations for moving forward.<\/p>\n","protected":false},"excerpt":{"rendered":"

Jennifer McPartland, Ph.D.,\u00a0is a Health Scientist. Readers of this blog are acutely aware of the dearth of data available for tens of thousands of chemicals in U.S. commerce today.\u00a0 This state of ignorance reflects legal and resource constraints as well as the \u201cchallenge\u201d of continuously integrating advancements in our scientific understanding of human health and …<\/p>\n","protected":false},"author":5105,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[56094,44,5009],"tags":[39167,39153,91637],"coauthors":[],"class_list":["post-4036","post","type-post","status-publish","format-standard","hentry","category-new-testing-methods","category-policy","category-health-science","tag-computational-toxicology","tag-data-requirements","tag-toxcast"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/4036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/users\/5105"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/comments?post=4036"}],"version-history":[{"count":0,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/4036\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/media?parent=4036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/categories?post=4036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/tags?post=4036"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/coauthors?post=4036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}