{"id":3880,"date":"2014-08-08T10:07:23","date_gmt":"2014-08-08T15:07:23","guid":{"rendered":"http:\/\/blogs.edf.org\/health\/?p=3880"},"modified":"2024-02-12T11:01:36","modified_gmt":"2024-02-12T16:01:36","slug":"twice-in-2-weeks-national-academy-of-sciences-again-strongly-affirms-federal-governments-science-agrees-formaldehyde-is-a-known-human-carcinogen","status":"publish","type":"post","link":"https:\/\/blogs.edf.org\/health\/2014\/08\/08\/twice-in-2-weeks-national-academy-of-sciences-again-strongly-affirms-federal-governments-science-agrees-formaldehyde-is-a-known-human-carcinogen\/","title":{"rendered":"Twice in 2 weeks: National Academy of Sciences again strongly affirms federal government\u2019s science, agrees formaldehyde is a known human carcinogen"},"content":{"rendered":"<p><em><em>Richard Denison, Ph.D.<\/em><em>,<\/em> is a Lead Senior Scientist.\u00a0<\/em><\/p>\n<p><span style=\"color: #000000;font-family: Calibri;font-size: medium\">Just last week <\/span><a href=\"https:\/\/blogs.edf.org\/health\/2014\/07\/29\/national-academy-of-sciences-strongly-affirms-science-showing-styrene-is-a-human-carcinogen\/\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">I blogged<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\"> that a <\/span><a href=\"http:\/\/www8.nationalacademies.org\/onpinews\/newsitem.aspx?RecordID=18725\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">panel of the National Academy of Sciences (NAS)<\/span><\/a><span style=\"font-family: Calibri\"><span style=\"color: #000000\"><span style=\"font-size: medium\"> had fully backed the National Toxicology Program\u2019s (NTP) listing of styrene as \u201creasonably anticipated to be a human carcinogen.\u201d<\/span><\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-family: Calibri;font-size: medium\">Today <\/span><a href=\"http:\/\/dels.nas.edu\/Study-In-Progress\/Review-Formaldehyde-Assessment\/DELS-BEST-12-04?bname=best\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">a separate NAS panel<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\"> strongly endorsed NTP\u2019s listing of formaldehyde as a \u201cknown human carcinogen\u201d in its <\/span><a href=\"http:\/\/ntp.niehs.nih.gov\/?objectid=03C9AF75-E1BF-FF40-DBA9EC0928DF8B15\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">12th Report on Carcinogens<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\"> (RoC).\u00a0 As with styrene, this second NAS panel both peer-reviewed the RoC listing and conducted its own independent review of the formaldehyde literature \u2013 and in both cases found strong evidence to support NTP\u2019s listing.\u00a0 See the NAS press release <\/span><a href=\"http:\/\/www8.nationalacademies.org\/onpinews\/newsitem.aspx?RecordID=18948\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">here<\/span><\/a><span style=\"font-family: Calibri\"><span style=\"color: #000000\"><span style=\"font-size: medium\">, which links to the full report.\u00a0 <!--more--><\/span><\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-family: Calibri;font-size: medium\">Recall that both of these NAS reviews were compelled by a rider slipped into the <\/span><a href=\"http:\/\/www7.nationalacademies.org\/ocga\/112Session1\/law-summaries\/index.htm\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">Consolidated Appropriations Act of 2012<\/span><\/a><span style=\"color: #000000\"><span style=\"font-family: Calibri;font-size: medium\"> by allies of the chemical industry, without any debate.\u00a0 The rider was one front in the industry\u2019s <\/span><\/span><a href=\"https:\/\/blogs.edf.org\/health\/2013\/03\/26\/the-chemical-industry-says-formaldehyde-and-styrene-dont-cause-cancer-only-one-of-52-scientists-agree\/\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">all-out war<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\"> to defend formaldehyde and styrene, two of its <\/span><a href=\"http:\/\/blogs.edf.org\/nanotechnology\/2011\/06\/13\/acc-resorts-to-smear-tactics-to-defend-its-cash-cows-formaldehyde-and-styrene\/\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">biggest cash cows<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\">, which also included an effort to <\/span><a href=\"https:\/\/blogs.edf.org\/health\/2012\/09\/05\/hands-off-the-report-on-carcinogens\/\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">cut off funding for the RoC<\/span><\/a><span style=\"font-family: Calibri\"><span style=\"color: #000000\"><span style=\"font-size: medium\">.<\/span><\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-family: Calibri;font-size: medium\">While the industry bought itself some time, the NAS formaldehyde panel\u2019s review of NTP\u2019s listing affirmed both NTP\u2019s conclusion and the <\/span><a href=\"https:\/\/blogs.edf.org\/health\/2013\/03\/26\/the-chemical-industry-says-formaldehyde-and-styrene-dont-cause-cancer-only-one-of-52-scientists-agree\/\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">rigor of NTP\u2019s scientific review<\/span><\/a><span style=\"color: #000000;font-family: Calibri;font-size: medium\">.\u00a0 The <\/span><a href=\"http:\/\/www.nap.edu\/catalog.php?record_id=18948\"><span style=\"color: #0000ff;font-family: Calibri;font-size: medium\">panel\u2019s report<\/span><\/a><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\"> notes (page 8):<\/span><\/span><\/span><\/p>\n<p style=\"padding-left: 30px\"><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">The committee concludes that NTP comprehensively considered available evidence and applied the listing criteria appropriately in reaching its conclusion. The 12th RoC states that \u201cformaldehyde is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans and supporting data on mechanisms of carcinogenesis.\u201d The committee agrees with NTP\u2019s conclusion, which is based on evidence published by June 10, 2011, that formaldehyde is a known human carcinogen.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">And based on its own independent assessment of the literature, the NAS panel concluded (page 13, emphases added):<\/span><\/span><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><span style=\"font-family: Calibri\"><span style=\"font-size: medium\">There is sufficient evidence of carcinogenicity from <b><i>studies of humans<\/i><\/b> based on consistent epidemiologic findings on nasopharyngeal cancer, sinonasal cancer, and myeloid leukemia for which chance, bias, and confounding factors can be ruled out with reasonable confidence.<\/span><\/span><\/span><\/li>\n<li><span style=\"color: #000000\"><span style=\"font-family: Calibri\"><span style=\"font-size: medium\">There is sufficient evidence of carcinogenicity <b><i>in animals<\/i><\/b> based on malignant and benign tumors in multiple species, at multiple sites, by multiple routes of exposure, and to an unusual degree with regard to type of tumor.<\/span><\/span><\/span><\/li>\n<li><span style=\"color: #000000\"><span style=\"font-family: Calibri\"><span style=\"font-size: medium\">There is convincing relevant information that formaldehyde induces <b><i>mechanistic events<\/i><\/b> associated with the development of cancer in humans, specifically genotoxicity and mutagenicity, hematologic effects, and effects on gene expression.<\/span><\/span><\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">In other words, the panel found that all three streams of evidence used (where available) to evaluate chemicals\u2019 toxicity to people \u2013 human epidemiological data, studies in laboratory animals, and mechanistic information \u2013 were consistent and strongly support the finding that formaldehyde causes cancer in people.\u00a0 And that it causes multiple types of cancer, at multiple sites in the body, via multiple routes of exposure, and through multiple mechanisms.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">With regard to the controversy over whether formaldehyde causes leukemia and other blood-related cancers, the NAS panel noted (page 13, emphasis added):<\/span><\/span><\/span><\/p>\n<p style=\"padding-left: 30px\"><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">The committee found clear and convincing epidemiologic evidence of an association between formaldehyde exposure and myeloid leukemia. There may also be an increase of other lymphohematopoietic cancers, although the evidence is less robust.\u00a0 \u2026\u00a0 The mechanistic events that were considered by the committee as relevant to the plausibility of formaldehyde-associated tumors beyond the portal of entry included genotoxicity and mutagenicity, hematologic effects, and effects on gene expression. Overall, in mechanistic studies of experimental animals and exposed humans, the evidence is largely consistent and strong. \u2026 The committee concludes that these findings provide plausible mechanistic pathways supporting a relationship between formaldehyde exposure and cancer, even though the potential mechanisms of how formaldehyde may cause such systemic effects are not fully understood. It would be desirable to have a more complete understanding about how formaldehyde exposure may cause systemic effects, but <b><i>the lack of known mechanisms should not detract from the findings of an association between formaldehyde exposure and myeloid leukemia in epidemiology studies<\/i><\/b>.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">In my last post on styrene, I concluded: \u201cOne can only hope that this sorry episode and waste of public resources will help to expose the narrow self-interest of the industry, which for years it has deceptively sought to wrap in a mantle of sound science.\u00a0 Now we know whose science is sound, and whose isn\u2019t.\u201d<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: Calibri\"><span style=\"font-size: medium\"><span style=\"color: #000000\">Times two.<\/span><\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-family: Calibri;font-size: medium\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Richard Denison, Ph.D., is a Lead Senior Scientist.\u00a0 Just last week I blogged that a panel of the National Academy of Sciences (NAS) had fully backed the National Toxicology Program\u2019s (NTP) listing of styrene as \u201creasonably anticipated to be a human carcinogen.\u201d Today a separate NAS panel strongly endorsed NTP\u2019s listing of formaldehyde as a &#8230;<\/p>\n","protected":false},"author":100,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[44,5009,56093],"tags":[39150,39164,5021,39160],"coauthors":[],"class_list":["post-3880","post","type-post","status-publish","format-standard","hentry","category-policy","category-health-science","category-industry-influence","tag-american-chemistry-council","tag-formaldehyde","tag-chemical-industry-tactics","tag-national-academy-of-sciences-nas"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/3880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/users\/100"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/comments?post=3880"}],"version-history":[{"count":1,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/3880\/revisions"}],"predecessor-version":[{"id":12712,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/posts\/3880\/revisions\/12712"}],"wp:attachment":[{"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/media?parent=3880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/categories?post=3880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/tags?post=3880"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/blogs.edf.org\/health\/wp-json\/wp\/v2\/coauthors?post=3880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}