{"id":11237,"date":"2022-10-19T09:54:24","date_gmt":"2022-10-19T14:54:24","guid":{"rendered":"https:\/\/blogs.edf.org\/health\/?p=11237"},"modified":"2025-12-09T13:44:45","modified_gmt":"2025-12-09T18:44:45","slug":"sperm-concerns-sons-affected-by-moms-exposure-to-forever-chemicals","status":"publish","type":"post","link":"https:\/\/blogs.edf.org\/health\/2022\/10\/19\/sperm-concerns-sons-affected-by-moms-exposure-to-forever-chemicals\/","title":{"rendered":"Sperm Concerns: Sons Affected by Mom\u2019s Exposure to Forever Chemicals"},"content":{"rendered":"<p><em>By <a title=\"Research Analyst, Safer Chemicals\" href=\"https:\/\/www.edf.org\/people\/lauren-ellis\">Lauren Ellis<\/a>, MPH, Research Analyst, Safer Chemicals<\/em><\/p>\n<p><strong>What&#8217;s New:<\/strong> A <a href=\"https:\/\/ehp.niehs.nih.gov\/doi\/full\/10.1289\/EHP10285\">peer-reviewed study<\/a> by Danish researchers found that a male fetus who is exposed to PFAS (per- and polyfluoroalkyl substances\u2014also known as \u201cforever chemicals\u201d) during early pregnancy is more likely to have lower sperm quality in early adulthood.<\/p>\n<p>It\u2019s the first study to explore the impact of exposure to more than two PFAS compounds (as measured in maternal blood samples during early pregnancy) on adult male reproductive hormones and sperm quality.<\/p>\n<p><strong>Why It Matters:<\/strong> Poor sperm quality is directly related to male infertility. In addition, it has been linked to other health problems such as <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26604070\/\">testicular cancer<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9253797\/#S4\">heart disease<\/a>, and <a href=\"https:\/\/academic.oup.com\/humrep\/article\/29\/7\/1567\/2914325\">all-cause mortality<\/a>.<\/p>\n<p>This study adds to <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4682569\/\">decades of literature<\/a> linking environmental chemical exposures to negative impacts on reproductive health.<\/p>\n<p><strong>Key Lessons from the Study:<\/strong><\/p>\n<ul>\n<li><strong>Women who were pregnant 20+ years ago had multiple types of PFAS in their blood.<\/strong> The study used data on a group of Danish women who were pregnant between 1998-2003. The women gave blood samples, which were then frozen and stored; 95% of those samples were taken in the first trimester of pregnancy.<\/li>\n<li style=\"list-style-type: none;\">In 2020-2021, researchers tested those maternal samples for 15 different PFAS compounds. They found 7 of the 15 in the bloodstream of nearly 90% of mothers in the study. The seven were: PFHxS, PFHpA, PFOA, PFOS, PFNA, PFDA, and PFUnDA.<\/li>\n<li><strong>Exposure to PFAS during pregnancy decreases the sperm quality of adult male offspring.<\/strong> Researchers found that both combined and single exposure to maternal PFAS concentrations during early pregnancy had a negative effect on the sperm quality\u2014particularly sperm count, concentration, and movement\u2014of adult male offspring.<\/li>\n<\/ul>\n<p><strong>Our Takeaway:<\/strong> The new study presents a startling finding\u2014developmental exposures to chemicals are associated with long lasting harm, including impacts that can affect future generations. It also adds to the growing evidence of PFAS health risks and demonstrates the <em>urgent<\/em> need for more health-protective PFAS policies and regulations.<\/p>\n<p><strong>Next Steps:<\/strong> EDF and our partners are pushing EPA to <a href=\"https:\/\/earthjustice.org\/sites\/default\/files\/files\/pfas_revocation_petition_submitted.pdf\">revoke existing PFAS exemptions<\/a> and require those PFAS (and new PFAS coming to market) to undergo a full safety review under the Toxic Substances Control Act, our nation\u2019s primary chemical safety law.<\/p>\n<p>It is critical that these evaluations also consider the cumulative risk of exposure to PFAS mixtures in the environment.<\/p>\n<p><strong>Note:<\/strong> In June 2021, EDF, with a group of health, environmental, and consumer organizations, <a href=\"https:\/\/blogs.edf.org\/health\/wp-content\/blogs.dir\/11\/files\/2021\/06\/PFAS-Petition-to-FDA-FINAL-6-1-21.pdf\">sent a formal petition<\/a> to FDA asking the agency to ban all PFAS\u00a0 that accumulate in the body. That petition is still under review.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By Lauren Ellis, MPH, Research Analyst, Safer Chemicals What&#8217;s New: A peer-reviewed study by Danish researchers found that a male fetus who is exposed to PFAS (per- and polyfluoroalkyl substances\u2014also known as \u201cforever chemicals\u201d) during early pregnancy is more likely to have lower sperm quality in early adulthood. It\u2019s the first study to explore the &#8230;<\/p>\n","protected":false},"author":148072,"featured_media":11238,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[56100,56096],"tags":[68,106773,5017,91722],"coauthors":[114040],"class_list":["post-11237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-emerging-science","category-omboira","tag-epa","tag-pfas","tag-risk-assessment","tag-risk-evaluation"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"description\" content=\"By Lauren Ellis, MPH, Research Analyst, Safer Chemicals What&#039;s New: A peer-reviewed study by Danish researchers found that a male fetus who is exposed to PFAS (per- and polyfluoroalkyl substances\u2014also known as \u201cforever chemicals\u201d) during early pregnancy is more likely to have lower sperm quality in early adulthood. It\u2019s the first study to explore the\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Lauren Ellis\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/blogs.edf.org\/health\/2022\/10\/19\/sperm-concerns-sons-affected-by-moms-exposure-to-forever-chemicals\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.9\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"EDF Health - Chemical Concerns \u2013 Insights on Air Pollution, Public Health, and Chemical Safety\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Sperm Concerns: Sons Affected by Mom\u2019s Exposure to Forever Chemicals\" \/>\n\t\t<meta property=\"og:description\" content=\"By Lauren Ellis, MPH, Research Analyst, Safer Chemicals What&#039;s New: A peer-reviewed study by Danish researchers found that a male fetus who is exposed to PFAS (per- and polyfluoroalkyl substances\u2014also known as \u201cforever chemicals\u201d) during early pregnancy is more likely to have lower sperm quality in early adulthood. It\u2019s the first study to explore the\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/blogs.edf.org\/health\/2022\/10\/19\/sperm-concerns-sons-affected-by-moms-exposure-to-forever-chemicals\/\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-10-19T14:54:24+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2025-12-09T18:44:45+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/edfhealth\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@EDFHealth\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Sperm Concerns: Sons Affected by Mom\u2019s Exposure to Forever Chemicals\" \/>\n\t\t<meta name=\"twitter:description\" content=\"By Lauren Ellis, MPH, Research Analyst, Safer Chemicals What&#039;s New: A peer-reviewed study by Danish researchers found that a male fetus who is exposed to PFAS (per- and polyfluoroalkyl substances\u2014also known as \u201cforever chemicals\u201d) during early pregnancy is more likely to have lower sperm quality in early adulthood. 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