EDF Health

MWCNT toxicity: Another dot to asbestos is connected

By / Published: March 25, 2009

Richard Denison, Ph.D., is a Senior Scientist.

Some months ago, my colleague John Balbus posted here about studies finding that when multi-walled carbon nanotubes (MWCNTs) are injected into the abdominal cavities of mice, they induce inflammation and mesothelioma-like reactions similar to those caused by asbestos.  He appropriately cautioned that – among other critical questions – these studies had not demonstrated that inhaled MWCNTs could actually move out of the lung and into the tissues where asbestos gives rise to its effects.  Well, that particular dot now appears to have been connected. Read More »

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Is the Window Closing?

By / Published: March 3, 2009

Richard Denison, Ph.D., is a Senior Scientist.

As one who has closely followed the emergence of nanotechnology, I am sure I was not alone several years ago in welcoming what appeared to be a refreshingly new attitude among a broad range of stakeholders toward the introduction of this new set of technologies and materials.  Calls from my organization to “get nanotech right the first time” were echoed widely.  Perhaps the most frequently used metaphor, though, was that a “window of opportunity” had opened to do things differently this time.  But I increasingly fear that the window is closing. Read More »

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Regulating nano-silver as a pesticide

By / Published: February 12, 2009

Cal Baier-Anderson, Ph.D., is a Health Scientist.

In May 2008, the International Center for Technology Assessment (ICTA) submitted a petition to EPA requesting that it regulate nano-silver used in products as a pesticide under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).  The petition calls on EPA to take the following specific actions:

  1. Classify nano-silver as a pesticide.
  2. Determine that nano-silver is a new pesticide and require its registration as such.
  3. Analyze the potential risks of nano-silver to human health and the environment.
  4. Take enforcement actions against nano-silver-containing products being sold illegally without EPA approval under FIFRA. Read More »
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Nano reporting goes mandatory

By / Published: February 10, 2009

Richard Denison, Ph.D., is a Senior Scientist.

It had to happen sooner or later. After several years spent by the UK and US governments conceptualizing, vetting, proposing, again vetting, developing, yet again vetting, and finally launching and reporting on their voluntary reporting programs for engineered nanoscale materials – only to have them largely spurned by the intended targets – other governments observing all this have decided that mandatory approaches are needed. Read More »

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Nano Confessions: EPA all but concedes mandatory reporting and testing are needed

By / Published: January 12, 2009

Richard Denison, Ph.D., is a Senior Scientist.

It’s been nearly a year since EPA launched its voluntary Nanoscale Materials Stewardship Program (NMSP) – and over three years since EPA was urged, by a diverse group of stakeholders, to do so only in conjunction with the development of mandatory reporting rules as a backstop and to limit the duration of the basic part of the program to at most six months.

EPA ignored that advice, and proceeded with an open-ended voluntary program and no development of backstop rules.  Now EPA has issued its first evaluation of the NMSP.  So what did EPA find? Read More »

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Nano’s Rapid Transit System

By / Published: December 12, 2008

Cal Baier-Anderson, Ph.D., is a Health Scientist.

In 2004, Gunter Oberdorster and colleagues demonstrated that upon inhalation, ultrafine particles, the dimensions of which are measured in nanometers, can move from the nasal passages of rodents to the brain via a specialized nerve called the olfactory bulb.  The evolutionary purpose of the olfactory bulb is to relay information about odors directly and rapidly from the nose to the brain.

The extent to which rapid transit via the olfactory bulb is a significant potential route of exposure to engineered nanomaterials is still an open question.  But two new papers add support for the relevance of this intriguing exposure pathway, raising important questions regarding the safety of inhaled nanoparticles.

Read More »

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