EDF Health

New study demands far more than a pregnant pause: Expectant women carry dozens of toxic chemicals in their bodies

By / Published: January 14, 2011

Richard Denison, Ph.D., is a Senior Scientist.

A long-awaited study documenting the presence of multiple toxic chemicals in the bodies of pregnant women was published today in Environmental Health Perspectives.  The study, conducted by researchers at Program on Reproductive Health and the Environment at the University of California, San Francisco, analyzed the most recent comprehensive biomonitoring data collected by the Centers for Disease Control (CDC) as part of its national human biomonitoring program.

The new study found widespread exposure of pregnant women to a large fraction of the chemicals for which biomonitoring is conducted, including chemicals that are currently in widespread use, such as brominated flame retardants (known as PBDEs) used in furniture foam and plastics, perfluorinated chemicals (PFCs) used in everything from packaging to textiles, and a pervasive environmental contaminant used in rocket fuel (perchlorate).

In particular the study noted:  “Certain PCBs, organochlorine pesticides, PFCs, phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons (PAHs) and perchlorate were detected in 99 to 100% of pregnant women.” (emphasis added)  Read More »

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Hitting ’em where it hurts: BPA reduces sperm quantity and quality in male workers

By / Published: October 28, 2010

Richard Denison, Ph.D., is a Senior Scientist.

As reported by Rob Stein in the Washington Post this morning, a NIOSH-funded study of male Chinese workers conducted by researchers at Kaiser-Permanente in Oakland, California has found that exposure to the endocrine-disrupting chemical bisphenol A (BPA) significantly increases the incidence of low sperm counts and concentrations, as well as lowered sperm motility and higher mortality.

The 5-year study, published in the peer-reviewed journal Fertility and Sterility (that’s a title only slightly more cheery than the CDC’s publication Morbidity and Mortality!), shows that the same kinds of adverse effects of BPA on sperm already observed in animal studies also occur in humans with detectable levels of BPA in their urine.

And while the most pronounced effects were observed in highly exposed workers, the authors of the study note:

Similar dose-response associations were observed among participants with only environmental BPA exposure at levels comparable to men in the general United States population.

Despite a markedly reduced sample size in this group of men exposed only to low environmental BPA sources, the inverse correlation between increased urine BPA level and decreased sperm concentration and total sperm count remain statistically significant.

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Are we ready to get sensible about triclosan use?

By / Published: April 9, 2010

Cal Baier-Anderson, Ph.D., is a Health Scientist.

Yesterday the Washington Post reported that the Food and Drug Administration (FDA) is acknowledging that new research raises “valid concerns” about the possible health effects of triclosan, an antimicrobial chemical that can be found in dozens of consumer products as diverse as soaps, personal care products, cutting boards, plastic sandals and even bath towels.

Originally developed as a surgical scrub for use by doctors and nurses, the burgeoning uses of this pesticidal chemical have hugely expanded human and environmental exposures.  With little evidence of any actual public health benefits from such uses, FDA along with the Environmental Protection Agency (EPA) and the Consumer Product Safety Commission (CPSC) should move quickly to limit triclosan use.  Only those uses that have a demonstrable public health benefit, when weighed against potential health and environmental risks, should be allowed. Read More »

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Toxic Chemicals in Consumer Products: More than Just Consumer Exposure

By / Published: February 8, 2010

Cal Baier-Anderson, Ph.D., is a Health Scientist.

An article recently published in the journal Macromolecules reports on the development of a new process that the authors claim can prevent the migration of phthalates from PVC plastic.   This “breakthrough” will undoubtedly be used to argue that industry should be allowed to continue to use a retinue of toxic chemicals in the manufacture of PVC destined for use in a broad variety of applications.

Concern for consumer exposures is often the main argument made against the use of toxic chemicals in consumer applications.  With evidence of exposure to chemicals like phthalates in nearly everyone who has been tested, including pregnant women, this is understandable.

But even if the new claims are proven to be true, there are many other reasons we need to find safer substitutes for such chemicals: worker exposures, environmental releases and end-of-life recycling and disposal issues, to name a few.  The potential impacts from continued use of toxic chemicals must be examined across their entire lifecycle. Read More »

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MWCNT toxicity: Another dot to asbestos is connected

By / Published: March 25, 2009

Richard Denison, Ph.D., is a Senior Scientist.

Some months ago, my colleague John Balbus posted here about studies finding that when multi-walled carbon nanotubes (MWCNTs) are injected into the abdominal cavities of mice, they induce inflammation and mesothelioma-like reactions similar to those caused by asbestos.  He appropriately cautioned that – among other critical questions – these studies had not demonstrated that inhaled MWCNTs could actually move out of the lung and into the tissues where asbestos gives rise to its effects.  Well, that particular dot now appears to have been connected. Read More »

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Nano’s Rapid Transit System

By / Published: December 12, 2008

Cal Baier-Anderson, Ph.D., is a Health Scientist.

In 2004, Gunter Oberdorster and colleagues demonstrated that upon inhalation, ultrafine particles, the dimensions of which are measured in nanometers, can move from the nasal passages of rodents to the brain via a specialized nerve called the olfactory bulb.  The evolutionary purpose of the olfactory bulb is to relay information about odors directly and rapidly from the nose to the brain.

The extent to which rapid transit via the olfactory bulb is a significant potential route of exposure to engineered nanomaterials is still an open question.  But two new papers add support for the relevance of this intriguing exposure pathway, raising important questions regarding the safety of inhaled nanoparticles.

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