Tag Archives: epigenetics

Linking everyday chemicals to disease: New science keeps on intensifying the writing on the wall

Richard Denison, Ph.D., is a Senior Scientist.

As a Washington policy geek, it’s sometimes hard not to let the ups and downs of political prospects for achieving real improvements in public health protections from toxic chemicals get me down.  The tenacity with which some stakeholders insist on throwing wrenches into the works to block efforts to reach middle ground is indeed depressing.

But through it all, there is one constant that continually restores my optimism that we’ll eventually get where we need to get to:  Science keeps moving forward and inexorably points toward the need for reform.  I will use this post to briefly highlight four recent studies that demonstrate the changing landscape of our knowledge of how environmental factors, including toxic chemical exposures, are affecting our health.  What’s noteworthy about these studies is that they all identified adverse health effects in human populations, and linked those effects to early-life exposures.  They all also illustrate the complex interplay between chemical exposures and social or other environmental factors that directly challenges the overly simplistic and non-scientific approach to causation that our chemicals policies have taken for decades.

Below are summaries of and links to these new studies:

  • Early-life exposure to PCE is associated with later-life risky behaviors.
  • Phthalate exposure is associated with excess weight in New York City children.
  • Exposure to perfluorinated chemicals may interfere with childhood vaccine effectiveness.
  • Epigenetic changes are associated with socio-economic status and biomarkers for cardiovascular disease.

Read More »

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Chemical safety evaluation: Limitations of emerging test methods

Jennifer McPartland, Ph.D., is a Health Scientist. Richard Denison, Ph.D., is a Senior Scientist.

Parts in this series:      Part 1     Part 2     Part 3     Part 4

This is the fourth in a series of blog posts on new approaches that federal agencies are exploring to improve how chemicals are evaluated for safety.  In this post, we’ll discuss a number of current limitations and challenges that must be overcome if the new approaches are to fulfill their promise of transforming the current chemical safety testing paradigm.  Read More »

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Could these chemicals make my grandchild look fat?

Richard Denison, Ph.D., is a Senior Scientist.

In an earlier post by my colleague Dr. Jennifer McPartland, she described new research that is linking certain chemical exposures to the rising epidemic of diabetes and obesity.  Some of that research, mainly conducted in laboratory animals, is revealing that when a mother is exposed to such chemicals before or during pregnancy, her offspring are more likely to suffer from diabetes and obesity as they mature.

How might such a proclivity toward development of diabetes and obesity later in life be transferred from one generation to the next, from mother to child?

In a word, epigenetics.   Read More »

Posted in Health Science | Also tagged , , | Comments closed
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