Selected tag(s): microbiome

A new power couple: The combined impact of the microbiome and chemical exposures on disease susceptibility (Part 2 of 2)

Allison Tracy is a Chemicals Policy Fellow. EDF Health Scientist Dr. Jennifer McPartland and Senior Scientist Dr. Richard Denison contributed to this post.

In Part 1 of this two-part post, I reviewed scientific evidence that the gut microbiome interacts with ingested chemicals to influence susceptibility to obesity and diabetes.  This hypothesis is the focus of a recent review article by Suzanne Snedeker and Anthony Hay.  Having reviewed evidence of the link between the microbiome and obesity and diabetes as well as the link between chemical exposures and obesity and diabetes, we now proceed to address this question:  Can the gut microbiome act in concert with ingested synthetic chemicals to predispose people to obesity and diabetes?

Read More »

Posted in Emerging Science, Health Science| Also tagged , , , , , , | Comments are closed

A new power couple: The combined impact of the microbiome and chemical exposures on disease susceptibility (Part 1 of 2)

Allison Tracy is a Chemicals Policy Fellow.  EDF Health Scientist Dr. Jennifer McPartland and Senior Scientist Dr. Richard Denison contributed to this post.

When you’re standing at the kitchen counter this holiday season wrestling with the nebulous world of weight gain, think about synthetic chemicals.  A good number of them are in you.  And studies show that some of them are pretty busy in there, interacting with various biological systems – including your metabolism.

But they’re not the only show in town.  Microbes are busy in your gut doing important things like digesting food and degrading harmful compounds.  But could they also influence the size of your love handles?  New science suggests that these microbes—in concert with certain chemicals—may have just this effect.

It is becoming increasingly clear that it’s not just your genes and your self control that determine your risk for obesity and related complications like diabetes.  Environmental factors are a big part of the equation, and those factors just might extend to synthetic chemicals to which you’re exposed, such as the flame retardants in your furniture and the plasticizers in food can linings.  Read More »

Posted in Emerging Science, Health Science| Also tagged , , , , , , , , | Read 1 Response

What are you, really? How our microbiome mediates chemical exposures

Allison Tracy is a Chemicals Policy Fellow. Richard Denison, Ph.D., is a Senior Scientist.

For millennia people have contemplated the question “who am I?”  But how about the even more fundamental question, “what am I”?  The human body is made up of about 10 trillion cells that form our tissues and organs.  But did you know that the human gut is the home to microbes that comprise 10 times more – that is, 100 trillion – cells?  And that, while the human genome contains about 23,000 genes, there are some 3 million genes in the microbes living in the human gut?  Obviously, this complicates things.  It arguably means we could be considered to be more microbe than human!

These numbers should tip us off to the importance of what is known as our “microbiome.”  New science is shedding light on the central function of the microbiome as a mediator between external agents to which we’re exposed and the impacts of those exposures.  Recent studies show, for example, that as chemicals pass through the gastrointestinal tract, they undergo major changes in bioavailability (i.e., how easily they are taken up into our bodies) and in their toxicity.  Recognition of the role of the microbiome is shifting the playing field for toxicology in fundamental ways.   Read More »

Posted in Emerging Science, Health Science| Also tagged , , , , , | Comments are closed
  • About this blog

    Science, health, and business experts at Environmental Defense Fund comment on chemical and nanotechnology issues of the day.
    Our work: Chemicals

  • Stay Updated

    Get blog posts and breaking news to your email inbox.

  • Filter posts by tags

    • ADHD (1)
    • aggregate exposure (10)
    • Air Pollution (1)
    • Alternatives assessment (3)
    • American Chemistry Council (ACC) (57)
    • Ami Zota (1)
    • arsenic (3)
    • artificial colors (1)
    • asthma (4)
    • Australia (1)
    • baby food (1)
    • behavior (1)
    • Behind the Label (1)
    • biomonitoring (9)
    • bipartisan (6)
    • bisphenol A (23)
    • Bleach (1)
    • blue (1)
    • bologna (1)
    • BP Oil Disaster (18)
    • BPA (1)
    • BPS (1)
    • Brain Development (1)
    • building code (1)
    • building code official (1)
    • California (2)
    • Canada (7)
    • carbon nanotubes (24)
    • carcinogen (22)
    • Carcinogenic Mutagenic or Toxic for Reproduction (CMR) (12)
    • CDC (8)
    • Center for Science in the Public Interest (1)
    • certified colors (1)
    • Chemical Assessment and Management Program (ChAMP) (13)
    • chemical exposure (2)
    • chemical identity (32)
    • chemical testing (4)
    • Chemicals in Commerce Act (3)
    • Chicago Tribune (6)
    • Children's health (2)
    • children's safety (24)
    • China (10)
    • chlorate (1)
    • Cincinnati (1)
    • citizens petition (2)
    • Cleveland (1)
    • Climate change (1)
    • Clinton (1)
    • color (1)
    • color additive (1)
    • computational toxicology (11)
    • Confidential Business Information (CBI) (60)
    • conflict of interest (8)
    • Congress (1)
    • Congressman Israel (1)
    • consumer products (52)
    • Consumer Specialty Products Association (CSPA) (4)
    • contamination (4)
    • CSPI (1)
    • cumulative exposure (4)
    • data requirements (47)
    • degradation (1)
    • DEHP (1)
    • dermal exposure (1)
    • Design for Environment (1)
    • development (2)
    • developmental (1)
    • diabetes (4)
    • disclosure (3)
    • DNA methylation (4)
    • Drinking Water (11)
    • drinking wtaer (1)
    • dry food (1)
    • DuPont (11)
    • Durbin (1)
    • dust (1)
    • endocrine (2)
    • endocrine disruption (31)
    • environmental justice (1)
    • EPA (9)
    • epigenetics (4)
    • exposure and hazard (49)
    • fast food (1)
    • FD&C (1)
    • FDA (18)
    • fees (1)
    • Firemaster (2)
    • flame retardants (25)
    • Flint (1)
    • Food (1)
    • food additive (3)
    • food additive petition (2)
    • food additives (2)
    • Food Advisory Comittee (1)
    • food contact substances (1)
    • food dyes (1)
    • formaldehyde (15)
    • fragrances (1)
    • front group (13)
    • GAO (1)
    • general interest (22)
    • Generally Recognizes as Safe (1)
    • George Washington University (1)
    • Globally Harmonized System (GHS) (5)
    • Government Accountability Office (5)
    • GRAS (3)
    • haz (1)
    • hazard (6)
    • health-based benchmark (2)
    • High Production Volume (HPV) (23)
    • home buyers (1)
    • home sales (1)
    • Household action level (3)
    • HUD (2)
    • hypochlorite (2)
    • ICC (1)
    • in vitro (14)
    • in vivo (11)
    • industry tactics (44)
    • Infants (1)
    • informed substitution (1)
    • inhalation (18)
    • International Code Council (1)
    • IUR/CDR (27)
    • Japan (3)
    • Lautenberg Act (59)
    • lead (23)
    • lead and copper rule (4)
    • lead dust hazard (2)
    • Lead Dust Standards (1)
    • Lead Exposure (6)
    • lead hazard (1)
    • Lead in Drinking Water (2)
    • lead poisoning preventon (1)
    • Lead Service Line (4)
    • lead-based paint (4)
    • Lead-safe (1)
    • lead-safe renovations firms (1)
    • lead-safe renovator (1)
    • LSHR (1)
    • LSL Replacement Collaborative (1)
    • Mapping (1)
    • markets (1)
    • Markey (1)
    • MCHM (1)
    • mercury (4)
    • methylene chloride (1)
    • methylmercury (2)
    • microbiome (3)
    • Milken Institute School of Public Health (1)
    • model (1)
    • nanodelay (4)
    • nanosilver (6)
    • National Academy of Sciences (NAS) (20)
    • National Institute for Occupational Safety and Health (NIOSH) (7)
    • National Institute of Environmental Health Sciences (NIEHS) (5)
    • National Nanotechnology Initiative (NNI) (7)
    • National Toxicology Program (1)
    • NCHH (1)
    • NDWA (1)
    • NDWAC (2)
    • New chemicals (8)
    • NHANES (1)
    • Nitrates (1)
    • NMP (1)
    • Obama (1)
    • obesity (6)
    • Occupational Safety and Health Administration (OSHA) (3)
    • Office of Information and Regulatory Affairs (OIRA) (4)
    • Office of Management and Budget (OMB) (16)
    • Office of Pollution Prevention and Toxics (OPPT) (3)
    • Ohio (1)
    • oil dispersant (18)
    • ortho-phthalate (1)
    • ortho-phthalates (1)
    • packaging (1)
    • paint (2)
    • PBDEs (19)
    • perchlorate (4)
    • Persistent Bioaccumulative and Toxic (PBT) (22)
    • personal care products (1)
    • pesticide (1)
    • pesticides (7)
    • PFOA (1)
    • phthalate (1)
    • phthalates (20)
    • pipes (1)
    • plastic packaging (1)
    • Podcast (1)
    • polycyclic aromatic hydrocarbons (PAH) (5)
    • prenatal (6)
    • prioritization (38)
    • Public Water Supplier (1)
    • PWS Water Board (1)
    • Quigley (1)
    • real estate (1)
    • red (1)
    • Redfin (1)
    • Reference Dose (1)
    • Regulatory Accountability Act (1)
    • renovation (1)
    • rental (1)
    • renters (1)
    • report on carcinogens (1)
    • reproductive (2)
    • residential code (1)
    • revised CSIA (4)
    • rice cereal (1)
    • right-to-know (1)
    • risk assessment (72)
    • risk evaluation (2)
    • RRP (1)
    • Safe Chemicals Act (24)
    • Safer Chemicals Healthy Families (33)
    • safety (2)
    • salami (1)
    • SB 1398 (1)
    • Science Advisory Board (1)
    • SDWA (1)
    • secrecy (1)
    • Sierra Club (1)
    • Significant New Use Rule (SNUR) (21)
    • Small business (1)
    • snur (1)
    • soil (1)
    • soil lead hazard (1)
    • South Korea (4)
    • State Senator Levya (1)
    • styrene (6)
    • Substances of Very High Concern (SVHC) (15)
    • systematic review (1)
    • TBB (2)
    • test rule (18)
    • Thiocyanate (1)
    • Toddlers (1)
    • toolkit (1)
    • total diet study (1)
    • Tox21 (5)
    • ToxCast (10)
    • toxic substances control act (1)
    • Transparency (2)
    • tributyltin (3)
    • trichloroethylene (TCE) (9)
    • TSCA inventory (1)
    • TSCA Modernization Act (14)
    • TSCA Reform (1)
    • TSCA Title IV (1)
    • Turkey (3)
    • U.S. states (17)
    • User Service Line (1)
    • Voluntary (1)
    • vulnerable populations (1)
    • Walmart (3)
    • Washington Post (1)
    • worker safety (23)
    • wristband (2)
    • WV chemical spill (12)
    • yellow (1)
    • Zillow (1)