EDF Health

Selected tag(s): in vitro

On the Road to In Vitro Testing: Are We There Yet?

John BalbusJohn Balbus, M.D., M.P.H., is Chief Health Scientist.

EPA’s recently released draft Nanotechnology Research Strategy (NRS) proposes a tiered testing system to evaluate human toxicity of nanomaterials.  It puts in vitro tests, or those done in test tubes and petri dishes as opposed to living animals, front and center.  EPA says the results of the first, in vitro tier will be used for guidance on “what health endpoints to monitor” and the second, in vivo tier will then help “identify those in vitro assays that correlate with in vivo nanomaterial toxicity or health effects.”

Wait a second.  If the in vivo testing is necessary in order to figure out what the in vitro testing results really mean, how can the agency use the in vitro testing results to figure out what health endpoints to monitor?  This cart and horse confusion is a serious matter. Read More »

Posted in Emerging Testing Methods, Health Science, Nanotechnology / Also tagged , | Read 1 Response

Nano “Trojan Horse” Study Gets Top Billing

John BalbusCal Baier-Anderson, Ph.D., is a Health Scientist.

Each year, the journal Environmental Science & Technology selects a list of Top Papers it has published that are “expected to have a significant and long-lasting impact on the field.” For 2007, its choice for the top environmental science paper addresses a curious facet of the behavior of certain metal oxide nanoparticles:  They can behave as “Trojan horses,” getting inside cultured lung cells and causing significant damage. Read More »

Posted in Health Science / Tagged | Read 2 Responses